Journal article
Herpes Simplex Virus ICP0 and ICP34.5 Counteract Distinct Interferon-Induced Barriers to Virus Replication
Abstract
Interferon inhibits virus replication through multiple mechanisms. Here we show that herpes simplex virus proteins ICP0 and ICP34.5 overcome interferon-induced barriers to viral transcription and translation, respectively. These cytokine-induced antiviral mechanisms are differentially expressed in established cell lines: U2OS cells do not mount the IFN-induced mechanism targeted by ICP0, and Vero cells may be defective for the mechanism …
Authors
Mossman KL; Smiley JR
Journal
Journal of Virology, Vol. 76, No. 4, pp. 1995–1998
Publisher
American Society for Microbiology
Publication Date
February 15, 2002
DOI
10.1128/jvi.76.4.1995-1998.2002
ISSN
0022-538X