Journal article
ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis
Abstract
BackgroundThe type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer. Both proteins are currently the subject of targeted therapeutics that are used in the treatment of breast cancer or which are in clinical trials. The focus of this study was to utilize our inducible model of IGF-IR overexpression to explore the interaction of these two potent oncogenes.ResultsErbB2 …
Authors
Campbell CI; Petrik JJ; Moorehead RA
Journal
Molecular Cancer, Vol. 9, No. 1,
Publisher
Springer Nature
Publication Date
December 2010
DOI
10.1186/1476-4598-9-235
ISSN
1476-4598