Journal article
Titin is a Target of Matrix Metalloproteinase-2
Abstract
BACKGROUND: Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function. Loss of titin in ischemic hearts has been reported, but the mechanism of titin degradation is not well understood. Matrix metalloproteinase-2 (MMP-2) is localized to the cardiac sarcomere and, on activation in ischemia/reperfusion injury, proteolyzes …
Authors
Ali MAM; Cho WJ; Hudson B; Kassiri Z; Granzier H; Schulz R
Journal
Circulation, Vol. 122, No. 20, pp. 2039–2047
Publisher
Wolters Kluwer
Publication Date
November 16, 2010
DOI
10.1161/circulationaha.109.930222
ISSN
0009-7322