Journal article
Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy
Abstract
Clostridium difficile causes increasing numbers of life-threatening intestinal infections. Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular auto-proteolysis following allosteric activation of their protease domains by inositol hexakisphosphate (IP6). Here, we explore the possibility of inactivating the C. difficile toxin B (TcdB) by triggering its …
Authors
Ivarsson ME; Durantie E; Huberli C; Huwiler S; Hegde C; Friedman J; Altamura F; Lu J; Verdu EF; Bercik P
Journal
Cell Chemical Biology, Vol. 26, No. 1, pp. 17–26.e13
Publisher
Elsevier
Publication Date
January 2019
DOI
10.1016/j.chembiol.2018.10.002
ISSN
2451-9456