Journal article
Degranulation of Human Platelets by the Thrombin Receptor Peptide SFLLRN: Comparison with Degranulation by Thrombin
Abstract
A new, simplified method of degranulating human platelets using the thrombin receptor peptide SFLLRN (20 microM) is described; released fibrinogen cannot be converted to fibrin, and the platelets are not exposed to a proteolytic enzyme, as they are when thrombin is used for degranulation. The peptide-degranulated platelets regain their disc shape and are recovered as single platelets which have released approximately 90% of the contents of …
Authors
Kinlough-Rathbone RL; Perry DW; Guccione MA; Rand ML; Packham MA
Journal
Thrombosis and Haemostasis, Vol. 70, No. 06, pp. 1019–1023
Publisher
Thieme
Publication Date
1993
DOI
10.1055/s-0038-1649718
ISSN
0340-6245