An evaluation of the serum FSH as a biomarker for ovarian toxicity in the rat

There is a need for a biomarker to evaluate numbers of oocytes in an ovary exposed to various exogenous toxicants. Experiments that had been previously reported were reviewed to assess the serum FSH as such a biomarker. Rats that had been exposed to direct ovarian radiation and direct ovarian radiation with cyclophosphamide were reviewed to ascertain the relationship of follicle numbers to the serum FSH. Under the conditions of reduced serum …