Journal article
PS1 - 170 Bmi1 is a Therapeutic Target in Recurrent Childhood Medulloblastoma
Abstract
Medulloblastoma (MB) is the most common malignant pediatric brain tumour, and is categorized into four molecular subgroups, with Group 3 MB having the worst prognosis due to the highest rate of metastatic dissemination and relapse. In this work, we describe the epigenetic regulator Bmi1 as a novel therapeutic target for treatment of recurrent Group 3 MB. Through comparative profiling of primary and recurrent MB, we show that Bmi1 defines a …
Authors
Garg N; Bakhshinyan D; Manoranjan B; Venugopal C; Hallett R; Mahendram S; Vijayakumar T; Subapanditha M; Qazi M; Singh M
Journal
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 43, No. S4, pp. s10–s10
Publisher
Cambridge University Press (CUP)
Publication Date
10 2016
DOI
10.1017/cjn.2016.358
ISSN
0317-1671