Journal article
Cyclin E expression in breast cancer: predicting germline BRCA1 mutations, prognosis and response to treatment
Abstract
BACKGROUND: Elevated levels of the cell cycle protein cyclin E, and low levels of its inhibitor, p27(Kip1), have been associated with a poor prognosis following breast cancer. Some studies have found that germline mutations in the breast cancer susceptibility gene, BRCA1, are also associated with an inferior survival rate. The relationship between cyclin E/p27(Kip1) levels, BRCA1 status and outcome has not been studied in detail.
PATIENTS AND …
Authors
Chappuis PO; Donato E; Goffin JR; Wong N; Bégin LR; Kapusta LR; Brunet J-S; Porter P; Foulkes WD
Journal
Annals of Oncology, Vol. 16, No. 5, pp. 735–742
Publisher
Elsevier
Publication Date
May 2005
DOI
10.1093/annonc/mdi149
ISSN
0923-7534
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedBRCA1 ProteinBRCA2 ProteinBiomarkers, TumorBreast NeoplasmsCohort StudiesCombined Modality TherapyCyclin EFemaleGene Expression Regulation, NeoplasticGenetic MarkersGerm-Line MutationHumansMiddle AgedNeoplasm StagingOncogene ProteinsPredictive Value of TestsProbabilityPrognosisRetrospective StudiesRisk AssessmentSensitivity and SpecificitySurvival AnalysisTreatment Outcome