Journal article
Effects of morphine on dopamine-stimulated adenylate cyclase and on cyclic GMP formation in primate brain amygdaloid nucleus
Abstract
In homogenates of Macacamulatta (Rhesus) or Cebusapella amygdaloid nuclear complex, adenylate cyclase activity was approximately doubled by either 10μM dopamine or 8mM NaF. In the presence of morphine, the stimulation by dopamine was reduced. A 90–100% inhibition of the dopamine stimulation was obtained with 20μM, and a 50% inhibition, with 5μM morphine. The effects of 10μM morphine on dopamine stimulation were reversed by 10μM naloxone. …
Authors
Wilkening D; Mishra RK; Makman MH
Journal
Life Sciences, Vol. 19, No. 8, pp. 1129–1137
Publisher
Elsevier
Publication Date
10 1976
DOI
10.1016/0024-3205(76)90247-2
ISSN
0024-3205