Journal article
Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis.
Abstract
Importance: Progression-free survival (PFS) has become a commonly used outcome to assess the efficacy of new cancer drugs. However, it is not clear if delay in progression leads to improved quality of life with or without overall survival benefit.
Objective: To evaluate the association between PFS and health-related quality of life (HRQoL) in oncology through a systematic review and quantitative analysis of published randomized clinical trials. …
Authors
Kovic B; Jin X; Kennedy SA; Hylands M; Pedziwiatr M; Kuriyama A; Gomaa H; Lee Y; Katsura M; Tada M
Journal
JAMA Internal Medicine, Vol. 178, No. 12, pp. 1586–1596
Publisher
American Medical Association (AMA)
Publication Date
December 1, 2018
DOI
10.1001/jamainternmed.2018.4710
ISSN
2168-6106