Journal article
An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer
Abstract
The nuclear proliferation biomarker Ki67 has potential prognostic, predictive, and monitoring roles in breast cancer. Unacceptable between-laboratory variability has limited its clinical value. The International Ki67 in Breast Cancer Working Group investigated whether Ki67 immunohistochemistry can be analytically validated and standardized across laboratories using automated machine-based scoring. Sets of pre-stained core-cut biopsy sections of …
Authors
Rimm DL; Leung SCY; McShane LM; Bai Y; Bane AL; Bartlett JMS; Bayani J; Chang MC; Dean M; Denkert C
Journal
Modern Pathology, Vol. 32, No. 1, pp. 59–69
Publisher
Elsevier
Publication Date
January 2019
DOI
10.1038/s41379-018-0109-4
ISSN
0893-3952