Journal article
Tetrandrine is not a selective calcium channel blocker in vascular smooth muscle.
Abstract
The effects of tetrandrine (Tet) on the contractile properties of rat aortic ring preparations were studied to test the hypothesis that Tet is a Ca2+ antagonist acting on voltage-operated Ca2+ channels (VOC). The tests were performed on contractions induced by depolarizing concentrations of KCl and by alpha 1-adrenoceptor agonist, phenylephrine (Phe). These vascular effects of Tet were compared to those of nifedipine (Nif). We found that Tet …
Authors
Kwan CY; Deng HW; Guan YY
Journal
Acta Pharmacologica Sinica, Vol. 13, No. 5, pp. 385–390
Publication Date
September 1992
ISSN
1671-4083