Journal article
Cytosolic calcium pre-elevation amplifies agonist-induced calcium release in human leukaemic HL-60 cells
Abstract
Histamine, ATP, and two microsomal Ca(2+)-pump inhibitors, thapsigargin (TG) and cyclopiazonic acid (CPA), were able to release intracellular Ca2+ in human leukaemic HL-60 cells. The relationships between the agonist-, TG- and CPA-sensitive Ca2+ pools were investigated with optimal concentrations of these agents in Ca(2+)-free medium. CPA failed to release Ca2+ after the Ca2+ stores of the cells had been discharged by TG, and vice versa, …
Authors
Leung YM; Kwan CY; Loh TT
Journal
Biochemical Journal, Vol. 302, No. 1, pp. 87–94
Publisher
Portland Press
Publication Date
August 15, 1994
DOI
10.1042/bj3020087
ISSN
0264-6021