Journal article
PROBING EXCITATION‐CONTRACTION COUPLING IN TRACHEALIS SMOOTH MUSCLE WITH THE MYCOTOXIN CYCLOPIAZONIC ACID
Abstract
1. Muscarinic stimulation-induced tonic contraction of airway smooth muscle is independent of membrane potential. This contraction is not sensitive to inhibition by voltage-operated Ca2+ channel blockers or by K+ channel openers. 2. Cyclopiazonic acid (CPA) inhibits Ca2+ loading of internal stores but does not affect maximal tonic contraction induced by acetylcholine (ACh) in steady state conditions. 3. After depletion of internal Ca2+ stores …
Authors
Amoako D; Qian Y; Kwan C; Bourreau J
Journal
Clinical and Experimental Pharmacology and Physiology, Vol. 23, No. 8, pp. 733–737
Publisher
Wiley
Publication Date
8 1996
DOI
10.1111/j.1440-1681.1996.tb01768.x
ISSN
0305-1870