Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells.

Abstract

The effects of tetrandrine (TET), a Ca2+ antagonist of Chinese herbal origin, and hernandezine (HER), a structural analogue of TET, on Ca2+ mobilization were studied in rat glioma C6 cells. TET and HER alone did not affect the resting cytoplasmic Ca2+ concentration ([Ca2+]i). TET and HER inhibited the peak and sustained elevation of [Ca2+]i induced by bombesin and thapsigargin (TG), a microsomal Ca2+ ATPase inhibitor, in a dose-dependent …

Authors

Imoto K; Takemura H; Kwan CY; Sakano S; Kaneko M; Ohshika H

Journal

Research Communications in Molecular Pathology and Pharmacology, Vol. 95, No. 2, pp. 129–146

Publication Date

2 1997

ISSN

1078-0297

Associated Experts

Chiu-yin Kwan

Professor Emeritus, Faculty of Health Sciences

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