Journal article
Desensitization of platelet alpha 2-adrenoceptors after short term infusions of adrenoceptor agonist in man.
Abstract
The effect of intravenous infusion of catecholamines and related drugs on human platelet alpha 2-adrenoceptor number and function was investigated. Short (60-120 min) infusions of catecholamines with alpha 2 agonist activity in vivo produced attenuation of the platelet responses to adrenaline in vitro. This desensitization was specific for the adrenaline induced aggregatory response. The maximum number of [3H]yohimbine binding sites on …
Authors
Jones CR; Giembcyz M; Hamilton CA; Rodger IW; Whyte K; Deighton N; Elliott HL; Reid JL
Journal
Clinical Science, Vol. 70, No. 2, pp. 147–153
Publisher
Portland Press
Publication Date
February 1, 1986
DOI
10.1042/cs0700147
ISSN
0143-5221