Journal article
Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.
Abstract
We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of NK-1 and NK-2 receptors in guinea pigs. We first established the efficacy and selectivity of (+/-) CP-96,345 (3 mg/kg i.v.) and of SR-48,968 (300 micrograms/kg i.v.) as NK-1 and NK-2 antagonists, respectively. (+/-) CP-96,345 substantially attenuated bronchoconstriction and …
Authors
Solway J; Kao BM; Jordan JE; Gitter B; Rodger IW; Howbert JJ; Alger LE; Necheles J; Leff AR; Garland A
Journal
Journal of Clinical Investigation, Vol. 92, No. 1, pp. 315–323
Publisher
American Society for Clinical Investigation
Publication Date
July 1, 1993
DOI
10.1172/jci116569
ISSN
0021-9738