Journal article
Identification of both NK1 and NK2 receptors in guinea‐pig airways
Abstract
1. NK1 and NK2 receptors have been characterized in guinea-pig lung membrane preparations by use of [125I-Tyr8]-substance P and [125I]-neurokinin A binding assays in conjunction with tachykinin-receptor selective agonists ([Sar9Met(O2)11]substance P for NK1 and [beta Ala8]neurokinin A (4-10) for NK2) and antagonists (CP-99,994 for NK1 and SR48968 for NK2). 2. The presence of high affinity, G-protein-coupled NK1 receptors in guinea-pig lung …
Authors
McKee KT; Millar L; Rodger IW; Metters KM
Journal
British Journal of Pharmacology, Vol. 110, No. 2, pp. 693–700
Publisher
Wiley
Publication Date
October 1993
DOI
10.1111/j.1476-5381.1993.tb13867.x
ISSN
0007-1188