Journal article
Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma
Abstract
The activity of CDP-840, a novel, selective phosphodiesterase IV inhibitor was determined in a leukotriene-dependent non-human primate model of allergic asthma. Measurements of specific airway resistance (sRaw) were recorded in a dual chamber plethysmograph for 1 h and 3-5 h after challenge of allergic conscious squirrel monkeys with an aerosol of ascaris antigen. Orally administered CDP-840 (10 mg/kg; 1 h before challenge) produced partial …
Authors
Jones TR; McAuliffe M; McFarlane CS; Piechuta H; Macdonald D; Rodger IW
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 76, No. 2, pp. 210–217
Publisher
Canadian Science Publishing
Publication Date
February 1, 1998
DOI
10.1139/y98-030
ISSN
0008-4212