Journal article
Inhibition of COX pathway in experimental myocardial infarction
Abstract
Release of inflammatory mediators within the ischemic myocardium has long been thought to contribute to myocardial damage and dysfunction. Myocardial infarction (MI) and congestive heart failure (CHF) were induced in rats by ligating the left coronary artery. Animals were treated with the selective cyclooxygenase-2 (COX-2) inhibitor-5,5-dimethyl-3-(3-fluorophenyl1)-4-(4-methyl-sulphonyl-2(5H)-fluranone (DFU), low-, high-dose acetyl salicylic …
Authors
Saito T; Rodger IW; Hu F; Robinson R; Huynh T; Giaid A
Journal
Journal of Molecular and Cellular Cardiology, Vol. 37, No. 1, pp. 71–77
Publisher
Elsevier
Publication Date
July 2004
DOI
10.1016/j.yjmcc.2004.04.002
ISSN
0022-2828
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAspirinCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDisease Models, AnimalEchocardiographyEndothelium, VascularFuransHeart FailureHeart VentriclesImmunohistochemistryInflammationIsoenzymesMyocardial InfarctionMyocardiumMyocytes, CardiacProstaglandin-Endoperoxide SynthasesRatsRats, Inbred Lew