Journal article
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
Abstract
The blood vessels of cancerous tumours are leaky1,2,3 and poorly organized4,5,6,7. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery8,9. Anti-angiogenic therapies—which ‘normalize’ the abnormal blood vessels in tumours by making them less leaky—have been shown to improve the delivery and effectiveness of chemotherapeutics with low molecular weights10, but it remains …
Authors
Chauhan VP; Stylianopoulos T; Martin JD; Popović Z; Chen O; Kamoun WS; Bawendi MG; Fukumura D; Jain RK
Journal
Nature Nanotechnology, Vol. 7, No. 6, pp. 383–388
Publisher
Springer Nature
Publication Date
June 2012
DOI
10.1038/nnano.2012.45
ISSN
1748-3387