Functional subtyping of histamine receptors on the canine proximal colonic mucosa.

The receptors involved in the neural and non-neural effects of histamine on the canine proximal colon in vitro were defined functionally by using selective agonists and antagonists. Two preparations, a ganglionated mucosa and an aganglionated epithelium, were set up in Ussing chambers and short-circuit currents were monitored. The mucosa was obtained by removing the circular and longitudinal muscles, but keeping intact the muscularis mucosa and …