Preparation, structure and cytotoxicity of cis-diammineplatinum(II) dinuclear complexes with 1-alkyluracil and imidate ligands

Abstract

A series of platinum dinuclear complexes with l-alkyluracil, cis-[Ph2(PtU)2(NH3)4] (NO3)2, cis-[Pt2(n-BuU)2(NH3)4](NO3)2, cis-[Ph2(BzlU)2(NH3)4](NO3)2 and cis-[Pt2(NaphCH2U)2(NH3)4](NO3)2 (head-to-head, where U=uracil), and with imide ligands, cis-[Ph2(SI2(NH3)4](NO3)2 (head-to-head), cis-[Pt2(DMGI)2(NH3)4](NO3)2 (head-to-head), cis-[Pt2(DMGI)2(NH3)4](NO3)2 (head-to-tail) and cis-[Pt2(DMGI)2(NH3)4] (NO3)2 (head-to-head, where SI = …