Journal article
Construction of a set of novel and robust gene expression signatures predicting prostate cancer recurrence
Abstract
We report here numerous novel genes and multiple new signatures which robustly predict prostate cancer (PC) recurrence. We extracted 696 differentially expressed genes relative to a reported PC signature from the TCGA dataset (n = 492) and built a 15-gene signature (SigMuc1NW) using Elastic-net with 10-fold cross-validation through analyzing their expressions at 1.5 standard deviation/SD below and 2 SD above a population mean. SigMuc1NW …
Authors
Jiang Y; Mei W; Gu Y; Lin X; He L; Zeng H; Wei F; Wan X; Yang H; Major P
Journal
Molecular Oncology, Vol. 12, No. 9, pp. 1559–1578
Publisher
Wiley
Publication Date
9 2018
DOI
10.1002/1878-0261.12359
ISSN
1574-7891