Journal article
Preferential Killing of Breast Tumor Initiating Cells by N,N-Diethyl-2-[4-(Phenylmethyl)Phenoxy]Ethanamine/Tesmilifene
Abstract
PURPOSE: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE; tesmilifene) is thought to potentiate the antineoplastic effect of cytotoxic drugs. In a phase III randomized trial for metastatic breast cancer using doxorubicin with or without DPPE, addition of the latter resulted in a significant improvement in overall survival and a trend toward a difference in progression-free survival but, paradoxically, no difference in objective tumor …
Authors
Deng T; Liu JC; Pritchard KI; Eisen A; Zacksenhaus E
Journal
Clinical Cancer Research, Vol. 15, No. 1, pp. 119–130
Publisher
American Association for Cancer Research (AACR)
Publication Date
January 1, 2009
DOI
10.1158/1078-0432.ccr-08-1708
ISSN
1078-0432