Anesthetic considerations in Smith-Lemli-Opitz syndrome

Purpose: Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive syndrome characterized by congenital anomalies affecting the airway, cardiorespiratory, gastrointestinal, genitourinary, and central nervous systems. The presence of these anomalies as well as the potential for musde rigidity with or without hyperthermia present challenges to anesthesia. This report describes our institution’s experience with SLOS patients undergoing …