Journal article
Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy
Abstract
BACKGROUND: Certain cancers depend for growth on uptake of cystine/cysteine from their environment. Here we examined advanced human prostate cancer cell lines, DU-145 and PC-3, for dependence on extracellular cystine and sensitivity to sulfasalazine (SASP), a potent inhibitor of the x(c)(-) cystine transporter.
METHODS: Cultures were evaluated for growth dependence on exogenous cystine, x(c)(-) transporter expression, response to SASP (growth …
Authors
Doxsee DW; Gout PW; Kurita T; Lo M; Buckley AR; Wang Y; Xue H; Karp CM; Cutz J; Cunha GR
Journal
The Prostate, Vol. 67, No. 2, pp. 162–171
Publisher
Wiley
Publication Date
February 1, 2007
DOI
10.1002/pros.20508
ISSN
0270-4137
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid Transport System ASCAnimalsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCell Line, TumorCell ProliferationCystineDose-Response Relationship, DrugHumansMaleMiceMice, Inbred NODMice, SCIDProstatic NeoplasmsReverse Transcriptase Polymerase Chain ReactionSulfasalazineXenograft Model Antitumor Assays