Journal article
Application of new acute kidney injury biomarkers in human randomized controlled trials
Abstract
The use of novel biomarkers of acute kidney injury (AKI) in clinical trials may help evaluate treatments for AKI. Here we explore potential applications of biomarkers in simulated clinical trials of AKI using data from the TRIBE-AKI multicenter, prospective cohort study of patients undergoing cardiac surgery. First, in a hypothetical trial of an effective therapy at the time of acute tubular necrosis to prevent kidney injury progression, use of …
Authors
Parikh CR; Moledina DG; Coca SG; Thiessen-Philbrook HR; Garg AX
Journal
Kidney International, Vol. 89, No. 6, pp. 1372–1379
Publisher
Elsevier
Publication Date
June 2016
DOI
10.1016/j.kint.2016.02.027
ISSN
0085-2538