Journal article
Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression.
Abstract
The ability of peroxisome proliferator-activated receptors (PPARs) to induce expression of a reporter gene linked to a peroxisome proliferator-responsive element (PPRE) from either the rat enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene or acyl-CoA oxidase [acyl-CoA:oxygen 2-oxidoreductase, EC 1.3.3.6] gene was examined by transient transfection assays in COS cells. Mouse and rat PPARs, as well as Xenopus PPAR alpha (xPPAR alpha) could …
Authors
Marcus SL; Miyata KS; Zhang B; Subramani S; Rachubinski RA; Capone JP
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 12, pp. 5723–5727
Publisher
Proceedings of the National Academy of Sciences
Publication Date
June 15, 1993
DOI
10.1073/pnas.90.12.5723
ISSN
0027-8424
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3-Hydroxyacyl CoA DehydrogenasesAcyl-CoA OxidaseAnimalsBase SequenceBinding SitesDNAEnoyl-CoA HydrataseGene Expression Regulation, EnzymologicIsomerasesKineticsLiverLiver Neoplasms, ExperimentalMiceMolecular Sequence DataMultienzyme ComplexesOligodeoxyribonucleotidesOxidoreductasesPeroxisomal Bifunctional EnzymeRatsReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearRestriction MappingTranscription FactorsTransfectionTumor Cells, CulturedXenopus