Journal article
The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo
Abstract
The peroxisome proliferator-activated receptor (PPAR) binds cooperatively to cognate peroxisome proliferator-responsive elements (PPRE) in vitro through heterodimerization with retinoid X receptors (RXR). We used the yeast two-hybrid system to determine whether these two nuclear receptors physically interact in vivo. Mouse (m) PPAR and human (h) RXR alpha were synthesized as fusion proteins to either the DNA-binding domain (GBD) or the …
Authors
Miyata KS; McCaw SE; Marcus SL; Rachubinski RA; Capone JP
Journal
Gene, Vol. 148, No. 2, pp. 327–330
Publisher
Elsevier
Publication Date
October 1994
DOI
10.1016/0378-1119(94)90707-2
ISSN
0378-1119