Journal article
Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways*
Abstract
The effects of distinct classes of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands on myogenesis and MyoD gene expression were examined in mouse skeletal muscle C2C12 myoblasts. Treatment of C2C12 cells with the PPARgamma ligand, 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), repressed morphologically defined myogenesis and reduced endogenous mRNA levels of the myogenic differentiation markers MyoD, myogenin, and …
Authors
Hunter JG; van Delft MF; Rachubinski RA; Capone JP
Journal
Journal of Biological Chemistry, Vol. 276, No. 41, pp. 38297–38306
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Publication Date
10 2001
DOI
10.1074/jbc.m103594200
ISSN
0021-9258