Journal article
Loss of class I MHC function alters behavior and stress reactivity
Abstract
The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunology in the past decade. Mice lacking both β-2microglobulin and transporter associated with antigen processing (β2M-/-TAP-/-) showed differences in basal behavior. In response to saline injection, β2M-/-TAP-/- mice showed a significant hypothalamic pituitary …
Authors
Sankar A; MacKenzie RN; Foster JA
Journal
Journal of Neuroimmunology, Vol. 244, No. 1-2, pp. 8–15
Publisher
Elsevier
Publication Date
3 2012
DOI
10.1016/j.jneuroim.2011.12.025
ISSN
0165-5728