Journal article
p21 is essential for normal myogenic progenitor cell function in regenerating skeletal muscle
Abstract
Despite the ability of myogenic progenitor cells (MPCs) to completely regenerate skeletal muscle following injury, little is known regarding the molecular program that regulates their proliferation and differentiation. Although mice lacking the cyclin-dependent kinase inhibitor p21 (p21-/-), develop normally, we report here that p21-/- MPCs display increased cell number and enhanced cell cycle progression compared with wild-type MPCs. …
Authors
Hawke TJ; Meeson AP; Jiang N; Graham S; Hutcheson K; DiMaio JM; Garry DJ
Journal
American Journal of Physiology - Cell Physiology, Vol. 285, No. 5, pp. c1019–c1027
Publisher
American Physiological Society
Publication Date
November 2003
DOI
10.1152/ajpcell.00055.2003
ISSN
0363-6143