Papaverine stimulates K+ turnover in resting rat hindlimb skeletal muscle

The purpose of this study was to describe the stimulation of K' turnover by papaverine (PAP) in resting skeletal muscle. Rat hindlimbs (n=5) were perfused for 20 min followed by 20 min with 10"5 M PAP. The perfusate contained bovine red blood cells, artificial plasma and 42K. Blood samples were analyzed for gases, ions, glucose, lactate, and 43K activity. Perfusate flow, arterial perfusate pressure and resting muscle tension were constant …