Skeletal muscle regeneration is attenuated with repression of the cytoskeletal protein, Xin

Xin, an actin binding protein, has been implicated in the regulation of satellite cell function and is hypothesized to be essential for skeletal muscle regeneration following injury. To investigate the role of Xin during skeletal muscle regeneration, we inhibited Xin expression using a Xin shRNA adenoviral (XinAd) injection into the right tibialis anterior (TA) of 6 week old male mice, while the left TA served as a control receiving an …