Maintenance of contractile properties despite impaired skeletal muscle oxidative metabolism in diet‐induced obesity.

Diet‐induced obesity (DIO) is increasing in prevalence among youth; a time where robust muscle growth occurs. We hypothesized that consumption of a high fat diet (HFD) in early adulthood would negatively impact mouse muscle metabolism and contractile function. HFD (~60% kcal fat for 8 weeks) induced an obese and insulin resistant phenotype with reduced relative muscle mass (72 ± 1.9%) compared to control. Using isolated single muscle fibers for …