Journal article
Activated protein C in sepsis and beyond: update 2006.
Abstract
Activated protein C (APC), a plasma serine protease, is best known for its ability to inhibit blood clot formation. APC acts as an anticoagulant by degrading coagulation cofactors Va and VIIIa, thereby attenuating the coagulation cascade. Over the past 15 years, impressive research advances have provided novel insights into the diverse biological activities of this molecule. APC is now viewed not only as an anticoagulant but also as a signaling …
Authors
Toltl LJ; Shin LYY; Liaw PCY
Journal
Frontiers in Bioscience-Landmark, Vol. 12, No. 1, pp. 1963–1972
Publisher
IMR Press
Publication Date
2007
DOI
10.2741/2202
ISSN
2768-6701