Journal article
Treatment of Prion Disease with Heterologous Prion Proteins
Abstract
Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment. The pathology of these diseases involves the conversion of a protease sensitive form of the cellular prion protein (PrPC) into a protease resistant infectious form (PrPsc or PrPres). Both in vitro (cell culture and cell free conversion assays) …
Authors
Skinner PJ; Kim HO; Bryant D; Kinzel NJ; Reilly C; Priola SA; Ward AE; Goodman PA; Olson K; Seelig DM
Journal
PLOS ONE, Vol. 10, No. 7,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0131993
ISSN
1932-6203