Journal article
Effects of neuropeptide Y and substance P on antigen-induced ion secretion in rat jejunum
Abstract
We previously described a model of intestinal hypersensitivity in which isolated gut segments from sensitized rats demonstrated a rapid epithelial secretory response to luminal antigen that was mediated by mucosal mast cells and capsaicin-sensitive nerves. In this study, we examined the ability of the inhibitory neuropeptide, neuropeptide Y (NPY), to diminish the antigen-induced secretory response. Rats were sensitized to egg albumin (EA), and …
Authors
McKay DM; Berin MC; Fondacaro JD; Perdue MH
Journal
American Journal of Physiology, Vol. 271, No. 6, pp. g987–g992
Publisher
American Physiological Society
Publication Date
December 1, 1996
DOI
10.1152/ajpgi.1996.271.6.g987
ISSN
0002-9513