Journal article
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
Abstract
BACKGROUND AND AIMS: Stress may be an important factor in exacerbating inflammatory bowel disease but the underlying mechanism is unclear. Defective epithelial barrier function may allow uptake of luminal antigens that stimulate an immune/inflammatory response. Here, we examined the effect of chronic stress on colonic permeability and the participation of mast cells in this response.
METHODS: Mast cell deficient Ws/Ws rats and +/+ littermate …
Authors
Santos J; Yang PC; Söderholm JD; Benjamin M; Perdue MH
Journal
Gut, Vol. 48, No. 5,
Publisher
BMJ
Publication Date
May 1, 2001
DOI
10.1136/gut.48.5.630
ISSN
0017-5749