Journal article
Platelet activation induced by porcine factor VIII (HYATE:C)
Abstract
We studied the effects of porcine factor VIII (P-FVIII; Hyate:C) and other coagulation products employed in the management of patients with hemophilia A, on platelet activation in vitro. Exposure of normal resting platelets to P-FVIII resulted in platelet activation, as manifested by increased expression of the platelet surface activation markers CD62, CD63, and activated-GPIIbIIIa, and by activation-induced modulation of expression of normal …
Authors
Chang H; Mody M; Lazarus AH; Ofosu F; Garvey MB; Blanchette V; Teitel J; Freedman J
Journal
American Journal of Hematology, Vol. 57, No. 3, pp. 200–205
Publisher
Wiley
Publication Date
March 1998
DOI
10.1002/(sici)1096-8652(199803)57:3<200::aid-ajh3>3.0.co;2-z
ISSN
0361-8609