High-Resolution Visualization of the Osteocyte Lacuno-Canalicular Network Juxtaposed to the Surface of Nanotextured Titanium Implants in Human

Osseointegration is controlled by a number of cellular mechanisms. Although factors governing bone formation are well-understood, the maintenance of bone at the bone-implant interface is less clear. Of some interest is the role of osteocytes, which via mechanotransduction are believed to be responsible for mechanical loading-based remodelling events in bone. Using a resin cast etching technique, we investigated the osteocyte lacuno-canalicular …