Journal article
Proton Pump Inhibitors and Risk of Fracture: A Systematic Review and Meta-Analysis of Observational Studies
Abstract
OBJECTIVES: Proton pump inhibitors (PPIs) are widely used in several acid-related gastrointestinal disorders. In vivo studies have suggested that gastric suppression by PPIs could result in decreased intestinal calcium absorption. Subsequently, there have been concerns that the chronic use of a PPI is associated with an increased risk of bone fracture. However, the results of clinical studies are conflicting.
METHODS: We performed a systematic …
Authors
Ngamruengphong S; Leontiadis GI; Radhi S; Dentino A; Nugent K
Journal
The American Journal of Gastroenterology, Vol. 106, No. 7,
Publisher
Wolters Kluwer
Publication Date
July 2011
DOI
10.1038/ajg.2011.113
ISSN
0002-9270