Journal article
Homology Model of Dihydropyridine Receptor: Implications for L-type Ca2+ Channel Modulation by Agonists and Antagonists
Abstract
L-type calcium channels (LCCs) are transmembrane (TM) proteins that respond to membrane depolarization by selectively permeating Ca(2+) ions. Dihydropyridine (DHP) agonists and antagonist modulate Ca(2+) permeation by stabilizing, respectively, the open and closed states of the channel. The mechanism of action of these drugs remains unclear. Using, as a template, the crystal structure of the KcsA K(+) channel (Doyle et al. (1998) Science 280, …
Authors
Zhorov BS; Folkman EV; Ananthanarayanan VS
Journal
Archives of Biochemistry and Biophysics, Vol. 393, No. 1, pp. 22–41
Publisher
Elsevier
Publication Date
September 2001
DOI
10.1006/abbi.2001.2484
ISSN
0003-9861
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsBacterial ProteinsBinding SitesBiophysical PhenomenaBiophysicsCalcium Channels, L-TypeIn Vitro TechniquesIon Channel GatingLigandsModels, MolecularMolecular Sequence DataMutagenesis, Site-DirectedNifedipinePotassium ChannelsProtein ConformationRabbitsSequence Homology, Amino Acid