Seasonal Distribution of Acute Myocardial Infarction in the Second National Registry of Myocardial Infarction 11The National Registry of Myocardial Infarction is supported by Genentech, Inc., South San Francisco, California. Genentech, Inc. reimburses ClinTrials Research, Inc. for the cost of data analysis and biostatistical services.

OBJECTIVES: This observational study sought to determine whether cases of acute myocardial infarction (AMI) reported to the second National Registry of Myocardial Infarction (NRMI-2) varied by season. BACKGROUND: The existence of circadian variation in the onset of AMI is well established. Examination of this periodicity has led to new insights into pathophysiologic triggers of atherosclerotic plaque rupture. Although a seasonal pattern for …