Postnatal Development of the Rat Exocrine Pancreas. I. Alterations in High- and Low-Affinity Cholecystokinin Receptors and Enzyme Secretion

We tested the hypothesis that postnatal alterations in cholecystokinin (CCK) receptors are associated with developmental changes in enzyme secretory response. We used simultaneous measurements of CCK receptor binding and amylase release in pancreatic acini isolated from rat pups at various ages (1, 2, 5, 6, 18, and 36 days). CCK receptor binding was analyzed using the LIGAND program. The affinity of the high-affinity state increased postnatally …