Journal article
Anticonvulsant-Induced Marrow Suppression and Immune Thrombocytopenia
Abstract
Phenytoin and carbamazepine are rarely associated with serious hematologic side effects but can include impairment of either humoral or cell-mediated immunity. We describe a patient who developed severe granulocytopenia while taking phenytoin. The phenytoin was replaced by carbamazepine and the patient subsequently developed erythroid hypoplasia, neutropenia and persistent thrombocytopenia. In vitro studies demonstrated a phenytoin-dependent …
Authors
Schweiger F-J; Kelton JG; Messner H; Klein M; Berger S; McIlroy WJ; Falk J; Keating A
Journal
Acta Haematologica, Vol. 80, No. 1, pp. 54–58
Publisher
Karger Publishers
Publication Date
1988
DOI
10.1159/000205599
ISSN
0001-5792