Journal article
Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence
Abstract
The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment encoding for the Bos taurus (cattle) albumin mRNA and subjected it to test-tube evolution to derive a catalytic DNA (DNAzyme) …
Authors
Gysbers R; Tram K; Gu J; Li Y
Journal
Scientific Reports, Vol. 5, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep11405
ISSN
2045-2322