Journal article
Interstitial cell of Cajal loss correlates with the degree of inflammation in the human appendix and reverses after inflammation
Abstract
BACKGROUND: Normal gut motility relies on the complex interaction between the interstitial cell of Cajal (ICC) and the enteric nerve networks. Inflammation of the gastrointestinal tract adversely affects both ICC and enteric nerves. We aimed to determine the distribution of ICC and nerve networks in patients with appendicitis.
METHODS: Specimens from controls and patients with appendicitis were examined with immunohistochemistry (c-Kit for ICC, …
Authors
Bettolli M; De Carli C; Cornejo-Palma D; Jolin-Dahel K; Wang X-Y; Huizinga J; Krantis A; Rubin S; Staines WA
Journal
Journal of Pediatric Surgery, Vol. 47, No. 10, pp. 1891–1899
Publisher
Elsevier
Publication Date
10 2012
DOI
10.1016/j.jpedsurg.2012.05.006
ISSN
0022-3468