Journal article
Estimation of treatment preference effects in clinical trials when some participants are indifferent to treatment choice
Abstract
BackgroundIn the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual way. Appropriate analysis of the data from both arms of the study allows investigators to estimate the impact on study outcomes of treatment preferences that patients may have, in addition to evaluating the usual direct effect of …
Authors
Walter SD; Turner RM; Macaskill P; McCaffery KJ; Irwig L
Journal
BMC Medical Research Methodology, Vol. 17, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s12874-017-0304-x
ISSN
1471-2288